Overview

SCIENTIFIC SCORE
Questionable
Based on 33 Researches
6.9
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin D-3 (as Cholecalciferol)
25 mcg (1,000 IU)
125%
Calcium (from Aquamin® TG Seaweed Derived Minerals and Calcium Citrate)
400 mg
31%
Magnesium (from Magnesium Oxide, Magnesium Glycinate, Magnesium Taurinate, Magnesium Citrate and Aquamin® TG Seaweed Derived Minerals)
800 mg
190%
Zinc (from L-OptiZinc® Monomethionine)
15 mg
136%

Top Medical Research Studies

9
Magnesium implantation improves heart recovery
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9
ZnO NPs protect heart health
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.

Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.

Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
8
Magnesium levels impact heart attack outcomes
We examined whether serum magnesium levels at admission could predict in-hospital outcomes for patients experiencing a heart attack.

In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.

Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.

Most Useful Reviews

9
Cramps resolved
I ordered this for my mother, who suffered from severe leg cramps. After two weeks of taking these tablets, her cramps disappeared, and we are immensely grateful. We took one tablet in the morning and another in the evening!
7.5
Essential nutrients
Calcium and magnesium are crucial for overall health. Calcium enhances bones and teeth, aiding nerve impulse transmission and muscle contraction. Meanwhile, magnesium ensures the heart, muscles, nerves, and circulation function correctly.
7.5
Effective supplement
This supplement is fantastic! Magnesium and calcium are vital, substantially strengthening bones and improving heart condition. I’ve taken it for two weeks, and it has truly made a difference. A package of 100 tablets will last quite a while.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 33 Researches
6.9
  • All Researches
9
Calcium's role in heart regeneration
We explored how calcium signaling influences heart cell proliferation, particularly after injuries like heart attacks. Our study centered on the L-Type Calcium Channel (LTCC) and how its inhibition might help heart cells regenerate. Remarkably, when we inhibited LTCC—either through pharmacological means or by enhancing the activity of an inherent inhibitor called RRAD—we observed significant boosts in heart cell activity.

This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.

Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
9
Magnesium implantation improves heart recovery
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.

Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.

Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
9
Magnesium scaffolds improve heart attack outcomes
We examined the performance of two types of bioresorbable scaffolds in patients experiencing acute coronary syndrome (ACS) - a common and serious manifestation of heart disease. Specifically, we compared the effectiveness of magnesium-based scaffolds, known as Magmaris, with the earlier polymer scaffolds called Absorb.

Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.

Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.

Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
9
ZnO NPs protect heart health
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.

Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.

Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
We investigated how zinc contributes to recovery after a heart attack, specifically focusing on its role in promoting heart health. The study centered on a new bioceramic material made from zinc and silicon oxide, which releases bioactive elements that work together to support heart cell function and reduce damage.

Our findings revealed that both zinc and silicon oxide enhance blood vessel growth and protect heart cells from harm during a heart attack. We observed that administering this material, either through injections or as a hydrogel, improved heart function and reduced scar tissue formation in a murine model of myocardial infarction.

This research marks a significant step in demonstrating the combined benefits of zinc and silicon oxide in heart protection. While zinc alone is part of the treatment, it’s essential to note that this study showcases their combined effects rather than evaluating zinc in isolation.

User Reviews

USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Cramps resolved
I ordered this for my mother, who suffered from severe leg cramps. After two weeks of taking these tablets, her cramps disappeared, and we are immensely grateful. We took one tablet in the morning and another in the evening!
7.5
Essential nutrients
Calcium and magnesium are crucial for overall health. Calcium enhances bones and teeth, aiding nerve impulse transmission and muscle contraction. Meanwhile, magnesium ensures the heart, muscles, nerves, and circulation function correctly.
7.5
Effective supplement
This supplement is fantastic! Magnesium and calcium are vital, substantially strengthening bones and improving heart condition. I’ve taken it for two weeks, and it has truly made a difference. A package of 100 tablets will last quite a while.
6
Postnatal support
Nice supplement! I took it for a month after giving birth, and I've noticed that my hair hardly falls out now, unlike after my first birth, where I had loads of hair in the bathroom. Magnesium serves as a good support for my heart muscle.
2
Calcium vs. magnesium
Nowadays, we hear incessantly about calcium's benefits. Yet, despite abundant calcium sources, dental and bone health still declines, leading to increased fragility and potential heart attacks. This is because calcium alone is ineffective; it must be consumed with magnesium for proper absorption and benefits.

Frequently Asked Questions

9
Cramps resolved
I ordered this for my mother, who suffered from severe leg cramps. After two weeks of taking these tablets, her cramps disappeared, and we are immensely grateful. We took one tablet in the morning and another in the evening!
7.5
Effective supplement
This supplement is fantastic! Magnesium and calcium are vital, substantially strengthening bones and improving heart condition. I’ve taken it for two weeks, and it has truly made a difference. A package of 100 tablets will last quite a while.
6
Postnatal support
Nice supplement! I took it for a month after giving birth, and I've noticed that my hair hardly falls out now, unlike after my first birth, where I had loads of hair in the bathroom. Magnesium serves as a good support for my heart muscle.
2
Calcium vs. magnesium
Nowadays, we hear incessantly about calcium's benefits. Yet, despite abundant calcium sources, dental and bone health still declines, leading to increased fragility and potential heart attacks. This is because calcium alone is ineffective; it must be consumed with magnesium for proper absorption and benefits.
7.5
Essential nutrients
Calcium and magnesium are crucial for overall health. Calcium enhances bones and teeth, aiding nerve impulse transmission and muscle contraction. Meanwhile, magnesium ensures the heart, muscles, nerves, and circulation function correctly.
7
Magnesium levels and mortality link
We investigated how variations in serum magnesium levels might relate to in-hospital mortality for patients experiencing an acute myocardial infarction (AMI), commonly known as a heart attack. The research examined data from over 2,700 patients in intensive care, allowing us to analyze trends over time.

What we found was significant: elevated magnesium levels at ICU admission and changes in magnesium levels within the first 48 hours of ICU stay were associated with a higher risk of in-hospital mortality among these patients. In fact, 18.6% of the patients in our study did not survive their hospital stay.

This relationship remained consistent across different groups, regardless of age, gender, or health severity scores. It highlights the importance of closely monitoring magnesium levels during crucial treatment periods as it may provide insight that could help tailor treatments to improve patient outcomes.

However, we must note that while the study shows an association, it does not isolate the effects of magnesium treatment itself. This means we can't definitively say that magnesium treatment alone drastically alters mortality rates after a heart attack. Instead, the findings suggest magnesium monitoring is vital in intensive care settings.
7
Magnesium levels impact kidney injury
We investigated how serum magnesium levels affect the risk of acute kidney injury (AKI) in patients who experienced ST segment elevation myocardial infarction (STEMI), a severe type of heart attack. In our study, we reviewed data from 1,219 patients, dividing them into two groups: those with hypomagnesemia (low magnesium levels) and those without. Hypomagnesemia was specifically defined as having a serum magnesium level of less than 0.75 mmol/L, a threshold that indicates deficiency.

Out of the participants, we found that 163 patients (about 13.4%) were hypomagnesemic, and alarmingly, 256 patients (21.0%) developed AKI during their hospital stay. The figures showed a significant disparity: AKI occurred in 31.9% of the hypomagnesemia group compared to 19.3% of those with normal magnesium levels, signaling a concerning association.

Our analysis indicated that hypomagnesemia is an independent risk factor for developing AKI, with a calculated odds ratio of 2.41. This suggests that patients with lower magnesium at admission face more than double the risk of experiencing kidney complications. These findings highlight the potential for magnesium interventions in heart attack recovery, suggesting that monitoring and managing magnesium levels could play a crucial role in improving patient outcomes and reducing the risk of kidney injury after a heart attack.
4
Magnesium's role in heart attack
We explored how serum magnesium levels relate to arrhythmias in patients experiencing acute myocardial infarction (AMI). Our study included detailed examinations and the calculation of a GRACE score for all participants, allowing us to categorize them based on their magnesium levels—whether normal or abnormal.

We observed that patients in the 51-60 age range were more likely to experience arrhythmias, particularly noting that although AMI was more common in men, the frequency of arrhythmias was somewhat higher in women. It's interesting to note that a significant number of patients with prolonged QTc intervals—an indicator of potential arrhythmias—had normal magnesium levels.

Of the patients found to have high levels of magnesium, about 36% developed arrhythmias. In contrast, those with low magnesium levels exhibited a 20% arrhythmia rate. We found a notable correlation between serum magnesium levels, QTc prolongation, and the GRACE scoring system, suggesting that magnesium plays a key role in the overall prognosis of AMI patients.

Ultimately, while we identified promising associations between magnesium levels and arrhythmias in the early stages of AMI, the study did not directly investigate magnesium as a treatment method. This limits our ability to determine its prospective therapeutic effects based solely on our findings.
8
Magnesium enhances heart attack recovery
We explored an innovative approach to treating myocardial infarction (MI) by using a special composite hydrogel that incorporates magnesium-modified black phosphorus nanosheets. This treatment aims to address the significant changes in the heart's environment after a heart attack, which are usually detrimental to recovery.

The research involved creating a hydrogel scaffold that allows for the gradual release of these magnesium-enhanced nanosheets directly at the site of the infarct. This is particularly important because sustained release helps to manage oxidative stress and inflammation, both common issues following a heart attack.

We observed that the black phosphorus nanosheets have a high reactivity with reactive oxygen species (ROS), which helps reduce oxidative stress and inflammation in the heart. Additionally, the magnesium contributes to promoting blood vessel growth, or angiogenesis, which is crucial for long-term heart function after an MI.

Overall, the findings of this study suggest that the combination of these elements in the hydrogel can effectively block further damage from the heart attack and improve recovery outcomes, signaling a promising avenue for heart attack treatments in the future.

References

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  2. Demirtola Aİ, Mammadli A, Çiçek G. The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI. Angiology. 2025. doi:10.1177/00033197251314629
  3. Jin Y, Lin Q, Wang D, Gong M, Huang W, et al. Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.12.006
  4. Naveen V, Rajesh Lenin R, Stanley LM, Kumar JS. Serum Magnesium Levels and QTc Interval Prolongation As Prognostic Markers in Acute Myocardial Infarction: A Randomized Controlled Study. Cureus. 2024;16:e66051. doi:10.7759/cureus.66051
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